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While semaglutide has demonstrated cardiovascular benefits in clinical trials, individual patients may experience complications unrelated to the medication that require assessment

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Muscogiuri G, DeFronzo RA, Gastaldelli A, Holst JJ (2017) Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes

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More studies using high quality MRS methods in a variety of brain regions are needed in the future to test this putative hypothesis