Vila Petroff MG, Egan JM, Wang X, Sollott SJ: Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes
Key facts about GLP-1-related gastroparesis: How it happens: GLP-1 drugs slow gastric emptying as part of their mechanism, but this effect becomes excessive in some people Whos at risk: Those with pre-existing digestive disorders, prior gastric surgery, long-standing diabetes, or elderly patients face higher risk Timeline: Symptoms can appear at any point during treatment, especially during dose increases Reversibility: Most cases improve after dose reduction or medication discontinuation, with recovery taking days to several months Management options: Dietary changes (smaller, low-fat meals), slower dose escalation, supportive medications, or temporary drug cessation Seek immediate medical attention for severe vomiting, dehydration signs, intense abdominal pain, or blood in vomit or stool
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Therefore, at least to some extent, AS should be considered as an autoimmune disease (Shoenfeld et al., 2001
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