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Neurorestorative therapies should therefore be evaluated not only by engraftment or lesion volume but also by their ability to restore metabolic homeostasis across the NVU (Fig
This represents an indirect mechanism that could enhance the bodys natural repair processes rather than replacing them with an external signal
Crucially, because the sample donors did not have a diagnosed cancer at the point IGF-1 was measured, this makes it highly likely that raised IGF-1 had a role in the cancer developing later
As such, it is possible that our results may have been different if samples were in storage for a greater duration of time
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