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PMID: 16740166

Tirzepatide on ingestive behavior in adults with overweight or obesity: a randomized 6-week phase 1 trial

Research suggests it may interact with several neurotransmitter and neuroendocrine systems rather than binding a single dedicated target

Acidosis is due to reduced feedback inhibition of -glutamyl cysteine synthetase in the gamma-glutamyl cycle, which ultimately leads to overproduction and accumulation of 5-oxoproline

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Glutathione peroxidase degrades intracellular hydrogen peroxide and thereby inhibits intracellular protein iodination in thyroid epithelium