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Tirzepatide vs Semaglutide Common Questions In the 2025 SURMOUNT-5 head-to-head trial, tirzepatide produced greater average weight loss 20.2% versus 13.7% with semaglutide over 72 weeks

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For people with obesity or diabetes , these effects together not only help manage blood sugar levels but also can contribute to weight loss by reducing hunger and caloric intake

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