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After talking to hundreds of patients with obesity over the years and to clinicians and researchers who study the disease, let me assure you: Reality looks a lot less like free will. Weight gain and weight loss are a complex orchestra of hormones that tell the body when were hungry and when were full
Some patients may notice mild gastrointestinal side effects such as nausea or diarrhea when starting tirzepatide
Changes tend to be more sustainable because you're building lasting habits rather than relying on a pharmaceutical intervention
Limitations A key limitation of this review is the heterogeneity of HFpEF as a clinical syndrome, which includes a broad range of phenotypes and comorbidity profiles, limiting direct comparability across trials
While the half-dozen men who spoke to me for this story largely said they had good experiences with compounded weight-loss drugs, doctors are concerned about the widespread use of compounded medications
Theres no evidence that Wegovy causes thyroid problems in people with a normal thyroid
