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Therefore, increases in kynurenine and its metabolites resulting from increased IDO activity could contribute to neuroinflammation, increased glutamate, altered immune system, depression, altered gut microbiota, and fatigue in ME/CFS patients [366, 367, 369]
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Presented for research literature review only Giordano G et al
However, additional concerns have been noted, including modest increases in heart rate observed in clinical trials and reports of dysesthesia, where normal sensations are perceived as painful, in some users
Effect sizes were estimated from meta-analysis of the BioBank Japan, MGI, and HUNT results only due to the differing effect size units of the CKDGen consortium results
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