Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis
The peptide in fact, can protect against prolongation of the QTc state of the heart in rats under daily administration of dopamine neuroleptics or prokinetics, which can lead to serious or even fatal arrhythmias
In preclinical co-administration studies, the effects are described as complementary
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