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Ipamorelin has been shown to stimulate GH secretion in vitro and in preclinical models with high receptor specificity, demonstrating minimal interaction with other endocrine pathways such as cortisol or prolactin release
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Encourages Sustainable Fat Loss: Supports gradual, maintainable body-composition changes rather than rapid, rebound-prone weight loss
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However, many PCOS patients who achieve significant weight loss and maintain it through diet and exercise see sustained improvement in cycle regularity and fertility even after stopping semaglutide
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