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The skin should be healthy and clear of lumps, bumps, or scars

The MTHFD2 encoded enzyme is an NAD + /NADP + -dependent enzyme that possesses 5,10-methylene-THF dehydrogenase and 5,10-methenyl-THF cyclohydrolase activities

Statements Author contributions HS: Conceptualization, Funding acquisition, Writing original draft

10.1038/s41564-018-0294-4 29 ChoC

Once the warning signs become unmistakable, the deficiency has typically been quietly growing for months