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About 10 percent of people on the highest orforglipron dose stopped the study because of side effects, compared with 2.6 percent of people on the placebo pill
RWJBarnabas Health System in New Jersey, for example, stopped covering GLP-1s for weight loss, though it will still cover them for diabetes, another condition these drugs commonly treat
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According to FDA prescribing information, nausea occurs in 15-44% of patients depending on the specific agent and dose, with vomiting affecting 5-24% and constipation occurring in 10-24% of users
So can chemical signals that act on melanocortin receptors in the skin
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