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GLP-1 receptor agonists cause fatigue primarily through indirect mechanisms including substantial caloric restriction from appetite suppression, gastrointestinal side effects leading to dehydration and nutritional deficits, and metabolic adaptation during weight loss
These would provide steady drug levels without weekly injection burden
Full effects may vary depending on your B12 levels and overall health
Vegans using semaglutide face a challenging combination
The BNF suggests the use of oral tablets to replace any dietary deficiency in B12 but does not recommend them for treating Pernicious Anaemia that should be treated with injections
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