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Healthcare providers need to overcome barriers related to the shortage and mitigate undesired negative consequences from an inability of patients with type 2 diabetes mellitus to obtain GLP-1 receptor agonist therapies amid this global access challenge

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Tirzepatide is the active ingredient in Zepbound, working as a dual GLP-1 and GIP receptor agonist to help regulate appetite, improve metabolism, and support weight loss

Another study conducted in 158 healthy male volunteers assessed the impact of different water volumes and post-dosing fasting periods on semaglutide exposure, and the authors concluded that administration of oral semaglutide in the fasting state with up to 120 mL of water and a post-dose fasting period of at least 30 min resulted in clinically relevant semaglutide exposure [31]

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