J Clin Pharm Ther 2003;28:289-94
3 million Canadians use GLP-1 drugs
John Buse, Director of the Diabetes Care Center at the University of North Carolina and a principal investigator in GLP-1 outcomes trials, has noted in published commentary that "the antioxidant milieu in type 2 diabetes is genuinely impaired, but whether exogenous supplementation corrects the underlying defect or simply raises circulating levels without tissue impact remains unresolved." [9] That distinction shapes the practical advice: correcting a documented deficiency (measured low whole-blood glutathione in a patient with poorly controlled diabetes) is a different clinical decision from empirically adding glutathione to a well-controlled patient already benefiting from dulaglutide's own oxidative-stress effects
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Glutathione is often referred to as a master antioxidant because of its unparalleled capacity to eliminate free radicals from the skin and renew it on all levels
Indirect effects come from losing body fat, particularly visceral fat, which is metabolically active and drives insulin resistance, elevated triglycerides, and low HDL