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doi: 10.3390/antiox11010050

In colonic tissue models, gabapentin was associated with: Reduced mast cell density or activation markers Decreased release of inflammatory mediators Improvement in visceral pain signaling These findings suggest gabapentin may exert indirect mast cellregulating effects within colonic tissue in experimental models

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On the other hand, local anesthetics like ethanol, also increase but decrease the bilayer thickness, beside other effects on the membrane structure such as inducing chain interdigitation and forming persistent non-bilayer structures at high enough concentrations (Figure 6B) [333]