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How was the GLP-1 agonist discovered

L-carnitine ameliorates oxidative damage due to chronic renal failure in rats [PMID: 15071358] Laboratory literature summary: L-carnitine ameliorates oxidative damage due to chronic renal failure in rats

In sensitive individuals, sustained elevation may cause gynecomastia or reproductive effects These hormonal effects are generally not observed at doses of 100 mcg or below Theoretical/Long-Term: Potential effects on glucose metabolism and insulin sensitivity with prolonged use As with all GH-elevating compounds, theoretical concern regarding promotion of growth in undiagnosed malignancies Water retention and tingling typically diminish within the first few weeks as the body adapts

Use non-oral method or add barrier method for 4 weeks after each change

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A: The principle is very similar