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GLP-1 medicines slow down digestion on purpose

Laboratory research record on GLP-1S [PMID: 42068314] PubMed laboratory record discussing GLP-1S in a research context

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What we have is a plausible biological hypothesis (collagen peptide supplementation provides the amino acid substrates that bone matrix formation depends on, which may be relevant when those substrates are being depleted by rapid weight loss) supported by a strong positive RCT in a related population - and no direct evidence yet in the GLP-1 therapy population specifically

Taking on an empty stomach facilitates faster absorption, while taking with food may reduce mild gastrointestinal irritation