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27 Glutathione thus shifts the equation of melanogenesis from eumelanin to pheomelanin through reactions between thiol groups and dopaquinone through formation of sulfhydryl-dopa conjugates

This peptide is the active ingredient in the topical copper peptides that have been sold as cosmetic agents on the dermatology shelf since the late 1980s, with the caveat being that topical GHK-Cu needs to penetrate the stratum corneum layer of skin before getting to the dermis, which houses the receptors for the peptide

Because the elastase component of this model produces acute proteolytic injury rather than chronic inflammatory remodeling, the findings need confirmation in CS-driven ACO models before any clinical extrapolation