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Phosphodiesterase-5 (PDE5) inhibitors such as sildenafil are often effective first-line treatments and are generally safe to use alongside GLP-1 medications, though they are contraindicated with nitrate medications and riociguat, and should be used with caution in unstable cardiovascular disease or if taking alpha-blockers
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The approval for Wegovy is based on a phase three trial that followed over 300 adults with obesity but not diabetes
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Do not rely on unproven supplements for managing a chronic disease
Furthermore, this treatment inertia is partly due to the absence of clear guidelines on how to reduce insulin doses when adding alternative glucose-lowering therapies, making it more likely that insulin therapy will continue uninterrupted
