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A recent meta-analysis assessing the effect of antidiabetic medications versus placebo in the treatment of acute depressive episodes did not support their efficacy in treating unipolar and bipolar depression, possibly because of the high heterogeneity of retained studies [165]
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If nausea begins within 20 minutes, facial flushing is pronounced, or erections last longer than 2 hours without ongoing stimulation, the dose is too high reduce by 0.250.5mg
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