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This lack of oversight raises concerns, since products can contain hidden drugs, banned substances, or incorrect dosages

Many of these products, which lack FDA oversight, make various unproven health claims

GrandtDSchimiczekMBeglingerCLayerPGoebellHEysseleinVEet al

ESSENCE Phase 3 semaglutide in MASH data supported FDA approval in March 2024 , creating a premium pricing tier in a disease category with USD 17.4 billion addressable market and no prior approved pharmacotherapy

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In some cases, patients required medical attention or hospitalization