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Sustained receptor engagement allows continuous activation of satiety pathways without repeated peaks and troughs

Early analyses suggest that retatrutide produces a body composition shift comparable to tirzepatide, where approximately 25-35% of total weight loss comes from lean mass and 65-75% from fat mass

Thus, changes in these biomarkers do not accurately assess real-time brain function since the underlying and established deficits in neuronal functioning are unaffected by their absence

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