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BMJ 388 , e080679 (2025)

GLP1-Promising Benefits: Originally developed for type 2 diabetes, has shown a range of positive effects beyond blood sugar regulation, especially in chronic disease prevention and management

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Studies suggest 10-20 times higher tissue concentrations compared to topical application of equivalent amounts

Lau J, Bloch P, Schaffer L, Pettersson I, Spetzler J, Kofoed J, Madsen K, Knudsen LB, McGuire J, Steensgaard DB, Strauss HM, Gram DX, Knudsen SM, Nielsen FS, Thygesen P, Reedtz-Runge S, Kruse T (2015) Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide