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For example, combined GLP-1 and GIP receptor deficiency is necessary to fully eliminate the glucose-lowering action of DPP-IV inhibition in mice 15 , -cell responsiveness to both GLP-1 736 and GIP is increased in T2D patients with improved glycemic control 16 , and DPP-IV inhibition can partially restore the insulinotropic effect of GIP in T2D patients 17