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When you fast, growth pathways like IGF-1 and mTOR are suppressed, which is needed for autophagy to occur

This leads to their destruction

doi: 10.1111/j.1365-2702.2008.02304.x 162 MoskwaJBorawskaMHMarkiewicz-ZukowskaRPuscion-JakubikANaliwajkoSKSochaKet al

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In humans, however, randomized trials with fertility endpoints are lacking