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Nrf2 depletion in macrophages leads to increased foam cell formation, increases the M1 inflammatory phenotype with enhanced expression of pro-inflammatory monocyte chemoattractant protein-1 and interleukin-6, and aggravates atherosclerosis (244, 245)
Because the circuits are partly distinct, the effects tend to add rather than overlap, and the combination can deliver more total appetite suppression at amounts that neither compound would need to reach alone
[17] [2] The UK SmPC advises caution in patients with pre-existing thyroid disease
Some individuals may see more noticeable changes in the first few months, while others may experience more subtle progress
Rheumatol (Oxford) (2020) 59:86978
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