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In the depressive brain, activation of mTOR is reduced, which subsequently decreases the release of BDNF and the synthesis of synaptic proteins (Jourdi et al., 2009)

It is an injectable medication, to be given once weekly, and is approved for use in type 2 diabetes, but likely to be popular for weight loss as well

However, genetic variants affecting oxidative stress management and metabolism may inform a broader conversation with your provider about supplement safety and efficacy

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335 Similar mechanisms underlie -synuclein propagation in PD, whereby lysosomal impairment enhances seeding, transmission, and progressive network degeneration

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