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Stones larger than 10 mm or that do not respond to conservative treatment may be treated with lithotripsy, ureteroscopy, or rarely, open surgery (Antonelli 2015)
As with all GLP-1 receptor agonists, there are class-level safety considerations to be aware of, based on UK Summary of Product Characteristics (SmPC) for approved agents such as semaglutide (Wegovy): Pancreatitis : If pancreatitis is suspected indicated by severe, persistent abdominal pain, which may radiate to the back treatment should be stopped immediately and urgent medical assessment sought
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While exenatide provides clinically meaningful glycemic control, its impact on weight loss is relatively modest compared to more recent GLP-1R agents, resulting in less than 3 kg of weight reduction over a 30-week period (DeFronzo et al., 2005
Contact the prescribing provider about persistent or severe symptoms
Scalebar is 20 m
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