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The poorer total and cell surface expressions observed with GIP/GLP-1R would be expected to impair agonist-induced endocytosis

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A common research framing is a defined block (often 812 weeks) followed by an off period, rather than indefinite continuous use a conservative default given the absence of long-term human data

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Kosiborod MN, Abildstrm SZ, Borlaug BA, et al