Receptor breaks may also be needed to prevent tolerance
Citalopram (Celexa) was followed by escitalopram (Lexapro), the active S-enantiomer, with a separate patent estate
This sequential approach serves two purposes: first, to eliminate immortal time bias by properly aligning treatment initiation with follow-up start (T0) and, second, to maximize statistical power by allowing individuals to contribute data across multiple trials
CL and KW conducted to the data analysis and manuscript drafting for this work
But claims on TikTok often leave out the risks involved
GLP-1 receptor activation suppresses appetite, slows gastric emptying, enhances glucose-dependent insulin secretion, and helps restrain inappropriate glucagon activity