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Oral peptide delivery: translational challenges due to physiological effects

For example, TNF activity reduces both ATGL and HSL expression at the level of the gene but induces increased lipase activity of pre-existing enzyme resulting in fatty acid and glycerol release from triglycerides

In contrast, the beneficial effects of SGLT2 inhibitors on albuminuria and eGFR decline in DKD were demonstrated by EMPA-REG OUTCOME (Wanner et al., 2016), CANagliflozin cardioVascular Assessment Study (CANVAS) (Perkovic et al., 2018), DECLARE-TIMI58 (Mosenzon et al., 2019b), and Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) (Perkovic et al., 2019)

Rocha BR, Gombar FM, Barcellos LM, et al

Contractor R, Konopleva M, Samudio I, Safe S, Andreeff M