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Remien et al.[10] recently developed a mathematical model to estimate overdosage of APAP based on indicators of liver damage (blood levels of aspartate aminotransferase, alanine aminotransferase and the international normalized ratio of prothrombin time) that are measured upon admission to hospital emergency departments

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No clinically validated dose exists, as these are clinical practice patterns, not trial-tested protocols

doi: 10.1159/000073087 155 NiwaYSumiHKawahiraKTerashimaTNakamuraTAkamatsuH

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The ranges below are extrapolated from rodent studies scaled to human bodyweight using allometric conversion, and reflect the most commonly cited research-protocol doses in the practitioner literature