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These tools do not replace provider instructions

Patients and providers still sought these therapies, but without a legal, regulated option, a gray market began to fill the gap, one characterized by unverified sources, inconsistent quality, and little to no pharmacist oversight.[5] In that environment, the very risks regulators aim to mitigate can become more difficult to control

showed that MTX-induced liver, kidney and heart damage was ameliorated with a flavonoid derivative diosmin (Reference Abdel-Daim, Khalifa and Abushouk47)

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