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For instance, a population of macrophages with high levels of SPP1 transcripts has been identified in tumors from patients with advanced metastatic castration-resistant prostate cancer (mCRPC), which suppressed CD8 + T-cell activity and promoted PD-1 resistance [182]

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Indeed, drug resistance is also related to increase discharge (efflux) of anticancer drugs due to the overexpression of the efflux transporters

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