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NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict

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In the case of vitamin B 12 there is no UL, as there is no human data for adverse effects from high doses

doi:10.1111/1467-9701.00431

Management strategies include eating smaller, more frequent meals