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Cetera GE, Merli CEM, Vercellini P
66 Tight Junctions The most prominent feature of the BBB is the presence of complex TJs between CNS ECs, which establish high transendothelial electrical resistance and determine the permeability of the BBB to hydrophilic molecules
TB-500 is a 43-residue acetylated polypeptide tracking the human Thymosin Beta-4 sequence, studied for G-actin sequestering activity and cytoskeletal remodelling in wound-healing assays
GPx4, lipid peroxidation, and cell death: Discoveries, rediscoveries, and open issues
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TB-500 operates systemically as a **cytoskeleton remodeler**: its primary function is G-actin monomer sequestration (active N-terminal Ac-Ser-Asp-Lys-Pro), its cleaved AcSDKP sequence is an **autonomous angiogenic factor**, it upregulates laminin-5 and matrix metalloproteinases (MMPs), and mobilizes mesenchymal progenitor cells
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