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Some of the findings include the following: In a 2022 trial, subjects taking 1,000mg of urolithin A exhibited clinically meaningful improvements in their aerobic endurance and physical performance when compared to subjects who took either 500mg or a placebo.5 A separate 2022 trial examined the effects of 1,000mg urolithin A versus placebo in older adults after four months of daily supplementation

In addition, 50 M DPA significantly reduced BV2 cell viability after stimulation with 100 ng/mL LPS, demonstrating that n-3 DPA may inhibit microglia-NF-B and MAPK p38 by balancing microglia M1 and M2 polarization (70)

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