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GLP-1 receptor agonists work by stimulating GLP-1 receptors in the body, which leads to several beneficial effects: Increased insulin secretion: GLP-1 receptor agonists promote insulin release from the pancreas, helping to lower blood sugar levels Reduced glucagon secretion: These medications inhibit the release of glucagon, a hormone that increases blood sugar levels, thereby reducing glucose production Slowed gastric emptying: GLP-1 receptor agonists slow down the emptying of the stomach, leading to increased feelings of fullness and reduced appetite Additionally, tirzepatide, the active ingredient in Mounjaro works on GIP receptors
Last, to what extend immune system is involved in the beneficial effects of GLP-1RAs on cardiometabolic and other diseases is not well understood
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The goal is not to stay on a maximum dose indefinitely
The mean baseline body weight was 93.2 kg, 95.5 kg and 92.9 kg in the placebo, liraglutide 1.8 mg and semaglutide tablets 14 mg arms, respectively
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