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Statements Author contributions Conceptualization: MH., MS, and BC
[1] [4] This reduces the risk of hypoglycaemia compared to some other diabetes medications, though this risk increases when combined with insulin or sulfonylureas
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Drugs 77, 17051711
Indeed, our single-cell RNA-seq (scRNA-seq) study in human islets found that transcripts that regulate alpha-cell maturity, such as ARX and DNMT1 , are differentially expressed across alpha-cell subpopulations, in which pseudotime analysis suggested that certain subpopulations are more mature than others (70), we found that the most immature subpopulation of alpha-cells also exhibited the highest expression of PCSK1 (gene name for PC1/3) ( PCSK1 -expressing alpha-cell subpopulation in response to intra-islet GLP-1R signaling (7478)
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