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This dose-finding study included 632 patients with T2D (mean diabetes duration 6.3 years and mean baseline HbA 1c 7.9%) and assessed the doseresponse relationship on glycemic control [mean change in hemoglobin A 1c (HbA 1c )] of once-daily oral semaglutide (2.5, 5, 10, 20, and 40 mg dose escalated over 4 weeks) versus placebo (double-blind) and s.c

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[15] Any persistent or severe vomiting or diarrhoea should be reported to the clinical trial team promptly

But calibrating expectations to real-world rather than trial-level outcomes prevents disappointment