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This modification not only promotes the de novo synthesis of serine and glycine, but also alleviates oxidative stress by increasing the production of GSH and NADPH to eliminate intracellular ROS, thus promoting the survival and proliferation of hepatocellular carcinoma cells in vitro and in vivo ( Another study has found that overexpression of FBXO7 inhibits the SSP by degrading PRMT1, inducing oxidative stress and suppressing tumor growth in hepatocellular carcinoma

Secondary plots of the k obs values from single exponential fits of the first phase and double exponential fits of the second phase against the GSSG concentration yielded a linear and hyperbolic correlation for the first and second phase, respectively (Fig