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An exploratory analysis of genetic data of patients from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trial showed that different haplotypes encoding for GLP-1R correlated with variable response rates to antipsychotic medications 132
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& Weissman, J
100% achieved 5% or more, 93% achieved 10% or more, and 83% achieved 15% or more in Phase 2
If you are lacking any of these three things then it may not make sense to take something that can potentially make your thyroid more difficult
Supplementation with 500-1,000 mcg daily or regular monitoring of serum B12 levels is advisable for at-risk individuals
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