Diabetes damages the brains blood vessels and neurons while obesity increases inflammation, which may increase the risk of dementia
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Within the hypothalamus the activation of GHS-1Ra in NPY and AgRP neurons is required for the orexigenic responses exerted by ghrelin release from A (X-like) cells in the stomach
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Hence, both CNS GIPR and GLP-1R signalling are required for the full weight loss effect of a GIPR-Ab/GLP-1 peptideantibody conjugate
Shen L, Li J, Chen Y, Lu Z, Lyu W