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who suggested that acetaminophen ingestion depletes intracellular GSH stores, which then causes loss of feedback inhibition of -glutamylcysteine synthetase activity (Figures 3a and 3b).This increases production of -glutamylcysteine, which is partially converted to pyroglutamic acid

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Recent research suggests that reduced glutathione may be an even more effective antioxidant than vitamins C and E, and it is considered the master antioxidant.

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doi: 10.1089/thy.2015.0592 98 LiDLiangGCalderoneRBellantiJA