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It works by stimulating lipolysis (the breakdown of fat) while inhibiting lipogenesis (the formation of new fat)

Units on a U-100 syringe: 0.045 mL 100 = 4.5 units (round to the ~45 unit mark on the barrel)

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Additionally, it is also used in the treatment of cyanide poisoning, a condition that can cause rapid breathing, confusion, and seizures

While estimands do not solve all problems of trial design and interpretation, this new concept will enable trials to be designed more appropriately to obtain relevant information to address the clinical question(s) of interest

They are not dosing recommendations or validated route conversions