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That gap matters more than most people re

Do not use syringes larger than 1mL for the actual injection, as the larger barrel makes precise measurements difficult

[2] Pharmacokinetic studies demonstrate rapid systemic distribution with peak plasma levels occurring within 30-60 minutes of intramuscular injection, followed by extensive hepatic storage and enterohepatic recycling

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Pulsatile secretion of hCG in normal adults [PMID: 3696177] Laboratory literature summary: Pulsatile secretion of hCG in normal adults

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