semaglutide and crohn's disease GLP-1 Use in Disease: Safety & IBD Considerations – PlexusDx The Potential for GLP-1s in

The functional concerns are different

Reflecting on the clinical implications, St-Pierre says that the findings support cautious use of GLP-1 RAs in selected patients with IBD when prescribed for approved metabolic indications, with appropriate counselling and monitoring. At the same time, she noted that the findings highlight substantial evidence gaps and believes future research should move beyond proxy outcomes and incorporate prospective, IBD-specific designs that integrate objective inflammatory measures with robust metabolic phenotyping. Moreover, there should be special considerations on the effects of GLP-1 RAs on body composition of patients with IBD, she adds

Discontinuation due to adverse events was 6.1-9.8% across dose groups versus 0% placebo

DOI: 10.1056/NEJM199508313330902 Ferrannini & DeFronzo (2015): Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes

doi: 10.1080/10715762.2018.1468564 7 Andriollo-SanchezM.Hininger-FavierI.MeunierN.VenneriaE.OConnorJ

This stress is often what causes that feeling of being "run down" or struggling to bounce back after a long weekend of adventure or hard training