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Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis

GlyNAC supplementation differentiates itself as a physiologic approach to correct glutathione deficiency, because it harnesses the cellular regulation of glutathione synthesis and reduces the risk of reductive stress, a phenomenon where excessive antioxidant intake pushes oxidation too low and disrupts normal cellular signaling

The trade-off is real, and the regulatory floor sits lower

More significant changes in hyperpigmentation or overall tone usually require 3 to 6 months of consistent use

doi:10.1186/gm367