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Elevated intracellular cAMP activates protein kinase A (PKA), which phosphorylates the cAMP response element-binding protein (CREB), driving transcription of melanogenesis-related genes including tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT) in melanocyte models
Hasegawa, Y., Hori, M., Nakagami, T., Harada-Shiba, M
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This mechanism may partially counteract any tachyphylaxis that develops to exogenous GLP-1 receptor agonism over time by maintaining endogenous secretion of the hormone
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