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Prednisolone increases appetite and may cause weight gain, potentially counteracting Wegovy's weight loss effects
Tirzepatide became the answer
By now, it has been established that the primary function of GLP-1 and GLP-1RA is to modulate brain regions that regulate appetite by influencing the release of neurotransmitters and peptides involved in hunger and energy balance
Patients who understand that the re-titration period is a necessary pharmacological bridge, not a step backward, are more likely to persist through the 12 weeks it takes to reach a therapeutic tirzepatide dose
Additionally, liraglutide and exenatide have been shown to reduce trunk fat content, particularly in the android region, a critical area linked to NAFLD and cardiovascular disease (CVD) risk [44]
It means the drug actively protects the heart beyond what weight loss alone would explain
